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1.
Acta Medica Philippina ; : 592-596, 2021.
Article in English | WPRIM | ID: wpr-987813

ABSTRACT

@#Epidermolytic Ichthyosis (EI) is a rare non-syndromic keratinopathic ichthyosis without definitive treatment. This is a case of EI in a 5-year-old Filipino female who presented with hyperkeratotic scales sparing the palms and soles. Histopathology revealed epidermolytic hyperkeratosis. A trial of treatment with isotretinoin 0.3 mg/kg/day, together with keratolytic agents, urea lotion and lactic acid lotion, resulted in a marked decrease in the thickness of the scales and odor. Interestingly, rebound effects were noted at 0.6 mg/kg/day. Taking into account that EI presents with more skin fragility compared to non-EHK ichthyosis, the authors surmise that there may be a smaller treatment window for patients with EI, which is notably lower than recommended for ichthyosis in general.


Subject(s)
Hyperkeratosis, Epidermolytic , Isotretinoin
2.
Rev. medica electron ; 42(5): 2408-2415, sept.-oct. 2020. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1144744

ABSTRACT

RESUMEN Las genodermatosis ictiosiformes constituyen un grupo heterogéneo de trastornos de la cornificación caracterizados por hiperqueratosis y descamación de la piel. La ictiosis arlequín es la forma más grave y agresiva de las ictiosis congénitas, presenta una baja prevalencia (1/300 000 nacimientos) con expresividad clínica variable, una evolución desfavorable y pronóstico reservado. Se presenta con un patrón autosómico recesivo y su diagnóstico prenatal es aún difícil. Se presentó el caso de un recién nacido masculino pretérmino de 34 semanas gestacionales, sin historia familiar de trastornos de piel, con un cuadro característico de ictiosis arlequín, quien falleció a los 11 días de vida. Se realizó la caracterización clínica y anatomopatológica de la enfermedad y se ofrece una revisión sobre esta rara entidad (AU).


ABSTRACT Ichthyosiform genodermatoses are a heterogeneous group of cornification disorders characterized by hyperkeratosis and skin flaking. Harlequin ichthyosis is the most aggressive and serious form of congenital ichthyoses, presenting a low prevalence (1/300 000 births), with variable clinical expressivity, an unfavorable evolution and reserved prognosis. It appears with an autosomal recessive pattern and its prenatal diagnosis is still difficult. The authors present the case of a male preterm newborn, of 34 gestational weeks, without family history of skin disorders, and clinical characteristics of Harlequin ichthyosis, who died at the 11 day of birth. The disease clinical and anatomopathologic characterization was carried out and a review of this rare entity is made (AU).


Subject(s)
Humans , Male , Infant, Newborn , Ichthyosis, Lamellar/diagnosis , Genetic Diseases, Inborn/diagnosis , Prenatal Diagnosis/methods , Ichthyosis, Lamellar/mortality , Ichthyosis, Lamellar/therapy , Ichthyosis, Lamellar/epidemiology , Hyperkeratosis, Epidermolytic/diagnosis , Critical Pathways/standards
3.
An. bras. dermatol ; 95(4): 477-479, July-Aug. 2020. graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1130906

ABSTRACT

Abstract Lymphangioma is a rare and understudied pathology that is usually detected in the first decade of life, and its appearance in adults is rare. This report details a 51-year-old man with morbid obesity who presented, for the last eight months, multiple asymmetric tumor lesions with extension to the scrotal region. The diagnosis of circumscribed lymphangioma with associated infection was confirmed. This case report demonstrates an unusual presentation of the characteristics of the lymphangioma that are seldom described in the literature.


Subject(s)
Humans , Male , Adult , Obesity, Morbid , Hyperkeratosis, Epidermolytic , Lymphangioma , Scrotum , Endothelial Cells , Middle Aged
4.
An. bras. dermatol ; 95(4): 484-489, July-Aug. 2020. tab, graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1130920

ABSTRACT

Abstract Annular epidermolytic ichthyosis is a rare subtype of epidermolytic ichthyosis that is characterized by erythematous, polycyclic, and migratory scaly plaques accompanied by palmoplantar keratoderma. This report presents the case of an 8-year-old girl who developed migratory, erythematous, scaly plaques associated with palmoplantar keratoderma. The initial hypothesis was erythrokeratodermia variabilis et progressiva; however, the finding of epidermolytic hyperkeratosis in histopathological examination led to the diagnosis of annular epidermolytic ichthyosis.


Subject(s)
Humans , Female , Child , Hyperkeratosis, Epidermolytic , Skin , Keratoderma, Palmoplantar , Exanthema
5.
Gac. méd. espirit ; 18(1): 99-105, ene.-abr. 2016.
Article in Spanish | LILACS | ID: lil-780689

ABSTRACT

Fundamento: La hiperqueratosis epidermolítica es una genodermatosis con patrón de herencia autosómico dominante, afecta a ambos sexos, es una enfermedad rara y se estima un caso cada 300 000 personas en las que predominan las ampollas al nacer y la hiperqueratosis subsiguiente. Objetivo: Describir el caso de un paciente con hiperqueratosis epidermolítica que representa una situación clínica infrecuente por su incidencia. Presentación de caso: Adolescente de 17 años, con lesiones de hiperqueratosis y presencia de escamas grandes de color oscuro, que se desprenden fácilmente en grandes colgajos epidérmicos, y que se acompaña de olor fétido. Conclusiones: Este caso constituye una ictiosis ampollosa de Siemens desde el punto de vista clínico, un subtipo de hiperqueratosis epidermolítica, aunque la histología solo confirmó este último diagnóstico.


Background: The Epidermolytic hyperkeratosis is a genodermatosis with pattern of inheritance dominant autosomal ,it affects equally to both sexes, it is a strange illness and he/she is considered a case each 300 000 people in those that the bladders prevail when being born and the subsequent hyperkeratosis. Objective: To describe the case of a patient with Epidermolytic hyperkeratosis that represents an uncommon clinical situation for their incidence. Case presentation: 17 year-old adolescent, with hyperkeratosis lesions and he/she witnesses of big flakes of dark color that come off easily in big epidermal torn pieces, and that he/she accompanies of fetid scent. Conclusions: This case constitutes an ICHTHYOSIS bullous of Siemens from the clinical point of view, a subtype of Epidermolytic hyperkeratosis, although the alone histology confirms this last one diagnostic.


Subject(s)
Hyperkeratosis, Epidermolytic/diagnosis
6.
An. bras. dermatol ; 90(6): 888-891, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769522

ABSTRACT

Abstract: Epidermolytic hipercetarose is a rare genodermatosis, with a prevalence of 1:100.000 to 1:300.000, with autosomal dominant inheritance. We report the case of a 5 year old girlwho presented an hypertrophic verrucous plaques in the neck, under arm, buttocks, knees, pelvis, legs, dorsum of the right foot and elbows. Histological examination of the skin lesions showed typical changes of epidermolytic hyperkeratosis. Because it is an autosomal dominant disorder with complete penetrance, the individual carrying the mutation will necessarily develop the disease. However, in 50% of cases postzygotic mutation occur. The case report emphasizes early diagnosis and differential diagnoses with ichthyosis and other bullous diseases of childhood, as well as discussing the therapeutic possibilities.


Subject(s)
Child, Preschool , Female , Humans , Hyperkeratosis, Epidermolytic/pathology , Diagnosis, Differential , Hyperkeratosis, Epidermolytic/therapy , Ichthyosis/pathology , Skin Diseases, Vesiculobullous/pathology , Skin/pathology
8.
Dermatol. peru ; 24(3): 172-175, jul.-sept. 2014. ilus
Article in Spanish | LILACS, LIPECS | ID: lil-765244

ABSTRACT

La enfermedad de Kyrle es una dermatosis perforante, poco frecuente, que predomina en adultos del sexo femenino principalmente con diabetes mellitus descompensada e insuficiencia renal crónica en hemodiálisis, de causa aún desconocida. Clínicamente es polimorfa con lesiones nodulo-queratósicas, centro crateriforme, en las extremidades inferiores con distribución ascendente y de curso crónico. Se presenta el caso de un varón de 70 años, procedente del Callao, sin antecedentes patológicos de importancia, que consulta al servicio de Dermatología por presentar lesiones pruriginosas descamativas en miembros superiores e inferiores desde hace 5 años. Al examen físico presenta pápulas y placas eritematovioláceos de superficie queratósica, duras a la palpación, huellas de rascado, principalmente a nivel de miembros superiores e inferiores. En la histopatología se observa tapón queratósico folicular con paraqueratosisfocal que se localiza en una zona de invaginación de la epidermis, que se encuentra adelgazada.


Kyrle's disease is an uncommon, perforating dermatosis prevalent in adult females mainly with decompensated diabetes mellitus and chronic renal failure on hemodialysis, being its cause remains unknown. Clinically is polymorphic with nodulokeratotics injuries, pitting in the lower extremities with chronic course upward and distribution center. The case of a man aged 70,jrom Callao no medical history of importance, consulting the dermatologist to present scaly itchy lesions 011 upper and lower limbs for 5 years is presented. Physical examination shows papules, erithematoviolaceous plaques and keratotic surface, hard to the touch, scratch marks, mainly at upper and lower limbs. Histopathology follicular keratotic plug with focal parakeratosis is observed which is located in an area of invagination of the epidermis, which is thinned.


Subject(s)
Humans , Male , Aged , Hyperkeratosis, Epidermolytic/diagnosis , Hyperkeratosis, Epidermolytic/pathology , Hyperkeratosis, Epidermolytic/therapy , Medical Illustration
9.
JPAD-Journal of Pakistan Association of Dermatologists. 2014; 24 (1): 86-88
in English | IMEMR | ID: emr-157648

ABSTRACT

Bullous Ichthyosiform Erythroderma [BIE] is a rare disorder of keratinization [mutation in either keratin 1 or 10]. It typically presents with fragile skin, which gives way to gradual evolution of hyperkeratosis. Flaccid blisters, peeling and superficial erosions at sites of minor trauma or friction are apparent within the first few hours of life. Yellow-brown, waxy, ridged or corrugated scale builds up in skin creases, sometimes forming spiny [Hystrix] outgrowths. Cobblestone-like keratoses occur at other sites such as the dorsal hands and feet and over the trunk. We report an 11-year-old boy with a generalized hyperkeratosis on the neck, trunk, extremities and scalp


Subject(s)
Humans , Male , Hyperkeratosis, Epidermolytic/pathology , Keratin-1 , Keratin-10 , Dermatitis, Exfoliative , Ichthyosis
10.
Med. U.P.B ; 32(2): 187-191, jul.-dic. 2013.
Article in Spanish | LILACS, COLNAL | ID: biblio-836883

ABSTRACT

Existe un grupo de desórdenes hereditarios de la cornificación, caracterizado por una excesiva acumulación de escamas en la piel, que varía desde leve y asintomático hasta amenazar la vida. El término ictiosis es derivado de la raíz griega "icti" que significa pescado. La Hiperqueratosis Epidermolítica (HE), también conocida como eritrodermia ictiosiforme congénita, es un desorden autosómico dominante de la cornificación, con una prevalencia de 1:100.000-300.000. Esta patología se evidencia al nacer o al poco tiempo por la presencia de ampollas y de eritrodermia. Existe un gran número de tipos de ictiosis, de los cuales, la mayoría son extremadamente raros. Entre los cuatro más comunes se encuentran: Ictiosis vulgar, Ictiosis ligada al gen X, Ictiosis lamelar, hiperqueratosis epidermolítica. Se presenta el caso de un paciente de 13 años, con diagnóstico clínico de hiperqueratosis epidermolítica que es llevado a consulta médica por compromiso severo de la piel.


There is a group of hereditary disorders of cornification characterized by an excessive accumulation of scales in the skin, which can range anywhere from mild and non-symptomatic to life threatening. The term ichthyosis derives from the Greek root "icti", which means fish. Epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma, is an autosomal dominant disorder of cornification with a prevalence of 1:100,000 ­ 300,000. EHK is evident at birth or soon thereafter, characterized by blistering and erythroderma. There are numerous types of ichthyosis, of which the majority are extremely rare. Vulgar ichthyosis, X-linked ichthyosis, lamellar ichthyosis, and epidermolytic ichthyosis are amongst the 4 most common types. The case report presented involves a 13-year-old patient with a clinical diagnosis of Epidermolytic hyperkeratosis who was taken to medical consultation presenting severely compromised skin.


Existe um grupo de desordens hereditárias da cornificação, caracterizados por uma excessiva acumulação de escamas na pele; a qual varia desde leve e assintomático até ameaçar a vida. O termo ictiosis é derivado da raiz grega "icti" o qual significa peixe. A Hiperqueratose epidermolítica (HE) também conhecida como eritrodermia ictiosiforme congênita, é uma desordem autossômico dominante da cornificación, com uma prevalência de 1:100.000 ­ 300.000. Esta patologia se evidência ao nascer ou ao pouco tempo deste; pela presença de ampolas e de eritrodermia. Existe um grande número de tipos de ictiosis, dos quais a maioria são extremamente raros. Entre os 4 mas comuns se encontram: Ictiosis vulgar, Ictiosis unida ao gene X, Ictiosis lamelar, hiperqueratose epidermolítica. Apresentasse-se o caso de um paciente de 13 anos, com diagnóstico clínico de hiperqueratose epidermolítica que é levado a consulta médica por compromisso severo da pele.


Subject(s)
Humans , Hyperkeratosis, Epidermolytic , Skin , Dermatitis, Exfoliative , Ichthyosis
11.
An. bras. dermatol ; 88(6,supl.1): 116-119, Nov-Dec/2013. graf
Article in English | LILACS | ID: lil-696816

ABSTRACT

Epidermolytic ichthyosis is a rare autosomal dominant disease that manifests at birth with fragile blisters and erosions that evolve into hyperkeratotic lesions associated or not with erythroderma. When the disease is associated with a mutation in cytokeratin 1, it may be related to hyperkeratosis of palms and soles, but this is not usually found when cytokeratin 10 is mutated. The disease can present in a mosaic form, due to post zygotic mutation of the gene involved, constituting an individual formed by two populations of genetically distinct cells - one carrier of the mutation and the other without it. We report a case of mosaic epidermolytic ichthyosis diagnosed in a female patient.


A ictiose epidermolítica é doença autossômica dominante rara que se manifesta ao nascer com bolhas frágeis e erosões que evoluem para lesões hiperceratóticas associadas ou não a eritrodermia. Quando associada à mutação da citoqueratina 1 pode estar relacionada à hiperceratose palmoplantar, porém quando o defeito está relacionado à mutação da citoqueratina 10, este achado não é comumente encontrado. A doença pode ainda se manifestar em forma de mosaicismo somático, devido a mutação pós zigótica do gene envolvido, formando um indivíduo com duas populações de células geneticamente distintas, uma com a mutação e outra sem a mutação. Relata-se um caso de ictiose epidermolítica em mosaico em paciente do sexo feminino.


Subject(s)
Adult , Female , Humans , Hyperkeratosis, Epidermolytic/pathology , Biopsy , Hyperkeratosis, Epidermolytic/genetics , Keratins/genetics , Mosaicism , Mutation
14.
An. bras. dermatol ; 86(4,supl.1): 72-75, jul,-ago. 2011. ilus, tab
Article in Portuguese | LILACS | ID: lil-604125

ABSTRACT

A hiperceratose epidermolítica é uma forma de ictiose geralmente resistente a tratamentos tópicos. Relata-se um caso de paciente feminina , em acompanhamento na dermatologia desde 1978, com diagnóstico de hiperceratose epidermolítica. Foi tratada inicialmente com queratolíticos, vitamina A oral, ácido tartárico e emolientes tópicos, porém sem melhora no quadro clínico, já que não haviam disponíveis outros tratamentos na época. Em 1986, com o advento dos retinóides orais, foi introduzido o etretinato, e em 1998, foi substituído pelo acitretin, apresentando excelente resposta terapêutica. No momento a paciente está em uso de acitretin 25 mg/dia, completando 23 anos de uso de retinóides orais, com mínimos efeitos adversos e melhora significativa na qualidade de vida.


Epidermolytic hyperkeratosis is a form of ichthyosis normally resistant to topical treatments. Female patient monitored since 1978 diagnosed with epidermolytic hyperkeratosis. Clinical examination showed generalized hyperkeratosis and scaling. Given that no other treatments were available at the time, the patient was initially treated with keratolytic, systemic vitamin A and moisturizers, with no improvement. In 1986, with the development of oral retinoids, etretinate was introduced. In 1998 this was replaced by acitretin. The patient is receiving 25 mg/day after 23 years of using oral retinoids. Significant improvement of the condition and patient's quality of life has been noted.


Subject(s)
Female , Humans , Middle Aged , Acitretin/therapeutic use , Hyperkeratosis, Epidermolytic/drug therapy , Retinoids/therapeutic use , Hyperkeratosis, Epidermolytic/pathology , Time Factors
15.
Chinese Journal of Medical Genetics ; (6): 421-423, 2011.
Article in Chinese | WPRIM | ID: wpr-326919

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the gene mutation in one sporadic case of bullous congenital ichthyosiform erythroderma (BCIE), and to explore the relationship between the genotype and phenotype.</p><p><b>METHODS</b>DNA was extracted from the blood samples of the patient with BCIE, unaffected members of the pedigree, and 50 unrelated healthy controls. PCR was used to amplify the hot spot fragment of keratin 1 (KRT1) and keratin 10 (KRT10) gene. The PCR products were directly sequenced to detect the mutations.</p><p><b>RESULTS</b>A heterozygous 467G>A mutation was found in the patient, resulting in the substitution of arginine (R) by histidine (H) in codon 156 (R156H) in the 1A domain of the KRT10 protein but not in the healthy individuals from the family and the 50 unrelated individuals.</p><p><b>CONCLUSION</b>The mutation of 467G>A in exon 1 of KRT10 gene identified may play a major role in the pathogenic mechanism of this case of BCIE.</p>


Subject(s)
Adolescent , Female , Humans , Base Sequence , DNA Mutational Analysis , Exons , Genetics , Hyperkeratosis, Epidermolytic , Genetics , Pathology , Keratin-10 , Genetics , Mutation
16.
Dermatol. argent ; 17(2): 140-145, mar.-abr.2011. tab, ilus
Article in Spanish | LILACS | ID: lil-723436

ABSTRACT

El término histológico de hiperqueratosis epidermolítica hace referencia a la presencia de hiperqueratosis, hipergranulosis y epidermolisis. Su expresión clínica es variable, e incluye a la ictiosis epidermolítica, su variedad en mosaico y la queratodermia palmoplantar epidermolítica, entre otros. Presentamos 5 casos con diagnóstico histológico de hiperqueratosis epidermolítica y diferentes cuadros clínicos de presentación. Casos clínicos. Dos casos presentaron la variedad en mosaico con aspecto de nevo verrugoso que sigue las líneas de Blaschko, uno con manifestación unilateral y el otro bilateral; un tercer paciente presentó queratodermia palmoplantar y los dos pacientes restantes, las variedades generalizadas: uno de ellos con eritrodermia y ampollas en etapa neonatal y el otro en el estadio hiperqueratósico. Conclusión. La hiperqueratosis epidermolítica representa un patrón histopatológico que se expresa con variadas formas clínicas, lo cual repercute en la calidad de vida de los pacientes y hace necesario el asesoramiento genético.


Subject(s)
Humans , Child , Hyperkeratosis, Epidermolytic/genetics , Hyperkeratosis, Epidermolytic/pathology , Ichthyosis/classification , Ichthyosis/genetics , Skin/pathology , Keratoderma, Palmoplantar/genetics , Keratoderma, Palmoplantar/pathology
17.
Pediatr. (Asunción) ; 37(3): 195-198, dic. 2010. graf
Article in Spanish | LILACS | ID: lil-598778

ABSTRACT

Introducción: El nevus epidérmico es una anomalía del desarrollo epidérmico que puede afectar cualquier parte del cuerpo, aunque se cita el predominio en las extremidades. Si bien esta entidad no es infrecuente, la presencia de hiperqueratosis epidermolítica en la biopsia cutánea es un hallazgo relativamente poco común, como lo demuestra la literatura consultada.Caso Clínico: Presentamos el caso de un paciente de sexo masculino de dos años de edad, con el diagnóstico de nevus epidérmico verrugoso lineal unilateral afectando el hemicuerpo izquierdo, con evidencias histopatológicas de hiperqueratosis epidermolítica. Discusión: El nevus epidérmico lineal unilateral es una forma rara de nevus epidérmico y también es inusual la presencia de hiperqeratosis epidermolítica. Se presenta generalmente dentro de los 5 primeros años de vida y las lesiones son intensamente pruriginosas. Estos nevos son frecuentemente refractarios al tratamiento tópico y la extirpación quirúrgica puede ser una opción para mejorar los síntomas.


Introduction: Epidermal nevus is an anomaly of epidermal development that can affect any part of the body, although usually reported in the extremities. Although it is not uncommon, the presence of epidermolytic hyperkeratosis on skin biopsy is a relatively uncommon finding in the literature. Case report: We report the case of a 2-year old male diagnosed with unilateral linear verrucous epidermal nevus of the left hemisphere with histopathological evidence of epidermolytic hyperkeratosis. Comments: Unilateral linear epidermal nevi are a rare form of epidermal nevus, and are also unusual in the presence of epidermolytic hyperkeratosis. They usually occur within the first 5 years of life and the lesions are intensely itchy. These nevi are often refractory to topical therapy and surgical removal may be an option to improve symptoms.


Subject(s)
Humans , Hyperkeratosis, Epidermolytic , Nevus , Pediatrics
18.
Dermatol. pediatr. latinoam. (Impr.) ; 8(1): 5-9, ene.-abr. 2010. ilus, tab
Article in Spanish | LILACS | ID: lil-598215

ABSTRACT

Los angioqueratomas son lesiones vasculares relativamente infrecuentes que consisten en pápulas hiperqueratósicas rojo-violáceas. Éstas pueden ser únicas o múltiples, estar localizadas en un solo segmento corporal o ser generalizadas y estar o no asociadas a otras enfermedades subyacentes. El presente trabajo abordará en profundidad los angioqueratomas localizados y se complementará con una segunda parte en la que se tratarán los angioqueratomas generalizados.


Angiokeratomas are a relatively non-frequent group of vascular lesions that consist on hyperkeratotic red-violaceous papules. Lesions can be solitary or multiple, localized or generalized and may be associated or not with a systemic disease. The present work is a throughout review on localized angiokeratomas and will be complemented with a second part in which generalized angiokeratomas will be discussed.


Subject(s)
Humans , Angiokeratoma , Fox-Fordyce Disease , Porokeratosis , Hyperkeratosis, Epidermolytic , Skin Neoplasms , Tongue Diseases
19.
SDJ-Saudi Dental Journal [The]. 2010; 22 (2): 95-98
in English | IMEMR | ID: emr-105818

ABSTRACT

Papillon-Lefevre syndrome [PLS] is a rare autosomal recessive disorder of keratinization, characterized by palmoplantar hyperkeratosis, periodontal involvement and precocious loss of dentition. The purpose of this report was to describe the case of an 18-year-old girl who presented to the out patient department of Navodaya Dental College and Hospital, Raichur, Karnataka, India, with the chief complaint of multiple loss of teeth. Her gingiva appeared erythematous, edematous and bled readily on probing, and the teeth were mobile. Hyperkeratosis of palms and soles were found. These findings are consistent with Papillon-Lefevre syndrome. The clinical presentation, differential diagnosis, complications and management of this syndrome are discussed


Subject(s)
Humans , Female , Genes, Recessive , Tooth Loss , Periodontitis , Hyperkeratosis, Epidermolytic , Keratoderma, Palmoplantar
20.
Dermatol. peru ; 19(3): 214-217, jul.-sept. 2009. ilus
Article in Spanish | LILACS, LIPECS | ID: lil-564499

ABSTRACT

El hemangioma verrucoso, es una malformación vascular poco frecuente. Básicamente consiste en una proliferación con dilataciones de vasos de distintos calibres que ocupan la dermis y la hipodermis. La epidermis de la zona afectada presenta una reacción proliferativa epidermal costosa que le da un aspecto verrucoso. Se presenta el caso de una paciente de 16 años, cuya enfermedad aparece desde el nacimiento, localizado en brazo derecho. Se analizan los aspectos clínicos y terapéuticos de esta afección.


Verrucous hemangioma is a rare vascular malformation. It basically consists of a proliferation with dilation of vessels of different sizes that occupy the dermis and hypodermis. The epidermis of that affected area presents a costly epidermal proliferative reaction that gives a warty appearance. A case of a 16 years old, whose disease appears at birth, located in right arm. We analyzed clinical and therapeutic aspect of this condition.


Subject(s)
Humans , Female , Adolescent , Hemangioma , Hyperkeratosis, Epidermolytic , Vascular Malformations , Warts
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